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| HUMAN GENERAL TRANSCRIPTION FACTOR-IIH PHOSPHORYLATES THE C-TERMINAL DOMAIN OF RNA POLYMERASE-II |
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| Author(s): LU H, ZAWEL L, FISHER L, EGLY JM, REINBERG D |
| Source: NATURE Volume: 358 Issue: 6388 Pages: 641-645 Published: AUG 20 1992 |
| Times Cited: 292 References: 35 |
| Abstract: Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. The transcription factor IIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, DEPT BIOCHEM, 675 HOES LANE, PISCATAWAY, NJ 08854 USA
2. FAC MED STRASBOURG, CNRS, GENET MOLEC LAB, INSERM, U184, F-67085 STRASBOURG, FRANCE |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JJ882 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |