| | |  | | | | Record from Web of Science® | | | | | | |
| TRANSACTIVATION BY AP-1 IS A MOLECULAR TARGET OF T-CELL CLONAL ANERGY |
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| Author(s): KANG SM, BEVERLY B, TRAN AC, BRORSON K, SCHWARTZ RH, LENARDO MJ |
| Source: SCIENCE Volume: 257 Issue: 5073 Pages: 1134-1138 Published: AUG 21 1992 |
| Times Cited: 314 References: 79 |
| Abstract: Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element. |
| Document Type: Article |
| Language: English |
Addresses:
1. NIAID, IMMUNOL LAB, BETHESDA, MD 20892 USA
2. NIAID, CELLULAR & MOLEC IMMUNOL LAB, BETHESDA, MD 20892 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JJ884 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |