| | |  | | | | Record from Web of Science® | | | | | | |
| CRYSTAL-STRUCTURES EXPLAIN FUNCTIONAL-PROPERTIES OF 2 ESCHERICHIA-COLI PORINS |
|
|
| Author(s): COWAN SW, SCHIRMER T, RUMMEL G, STEIERT M, GHOSH R, PAUPTIT RA, JANSONIUS JN, ROSENBUSCH JP |
| Source: NATURE Volume: 358 Issue: 6389 Pages: 727-733 Published: AUG 27 1992 |
| Times Cited: 990 References: 58 |
| Abstract: Porins form aqueous channels that aid the diffusion of small hydrophilic molecules across the outer membrane of Gram-negative bacteria. The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel beta-barrel containing a pore. A long loop inside the barrel contributes to a constriction of the channel where the charge distribution affects ion selectivity. The structures explain at the molecular level functional characteristics and their alterations by known mutations. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV BASEL, BIOCTR, DEPT STRUCT BIOL, CH-4056 BASEL, SWITZERLAND
2. UNIV BASEL, BIOCTR, DEPT MICROBIOL, CH-4056 BASEL, SWITZERLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JK699 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |