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| GENE FUSION WITH AN ETS DNA-BINDING DOMAIN CAUSED BY CHROMOSOME-TRANSLOCATION IN HUMAN TUMORS |
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| Author(s): DELATTRE O, ZUCMAN J, PLOUGASTEL B, DESMAZE C, MELOT T, PETER M, KOVAR H, JOUBERT I, DEJONG P, ROULEAU G, AURIAS A, THOMAS G |
| Source: NATURE Volume: 359 Issue: 6391 Pages: 162-165 Published: SEP 10 1992 |
| Times Cited: 864 References: 34 |
| Abstract: EWING'S sarcoma and related subtypes of primitive neuroectodermal tumours share a recurrent and specific t(11; 22) (q24; q12) chromosome translocation1-8, the breakpoints of which have recently been cloned9. Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions where the breakpoints of chromosome 22 and chromosome 11 are, respectively, have allowed identification of transcribed sequences from these regions and has indicated that a hybrid transcript might be generated by the translocation9. Here we use these fragments to screen human complementary DNA libraries to show that the translocation alters the open reading frame of an expressed gene on chromosome 22 gene by substituting a sequence encoding a putative RNA-binding domain for that of the DNA-binding domain of the human homologue of murine Fli-1. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST CURIE, GENET TUMEURS LAB, 26 RUE ULM, F-75231 PARIS 05, FRANCE
2. ST ANNA CHILDRENS HOSP, CHILDRENS CANC RES INST, A-1090 VIENNA, AUSTRIA
3. MCGILL UNIV, CTR RECH NEUROSCI, MONTREAL H3G 1A4, QUEBEC CANADA
4. LAWRENCE LIVERMORE NATL LAB, CTR HUMAN GENOME, LIVERMORE, CA 94550 USA
5. INST CURIE, CNRS, URA 620, F-75231 PARIS 05, FRANCE |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JM494 |
| ISSN: 0028-0836 |
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