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| ESTIMATION OF LEVELS OF GENE FLOW FROM DNA-SEQUENCE DATA |
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| Author(s): HUDSON RR, SLATKIN M, MADDISON WP |
| Source: GENETICS Volume: 132 Issue: 2 Pages: 583-589 Published: OCT 1992 |
| Times Cited: 456 References: 19 |
| Abstract: We compare the utility of two methods for estimating the average levels of gene flow from DNA sequence data. One method is based on estimating F(ST) from frequencies at polymorphic sites, treating each site as a separate locus. The other method is based on computing the minimum number of migration events consistent with the gene tree inferred from their sequences. We compared the performance of these two methods on data that were generated by a computer simulation program that assumed the infinite sites model of mutation and that assumed an island model of migration. We found that in general when there is no recombination, the cladistic method performed better than F(ST) while the reverse was true for rates of recombination similar to those found in eukaryotic nuclear genes, although F(ST) performed better for all recombination rates for very low levels of migration (Nm = 0.1). |
| Document Type: Article |
| Language: English |
| Reprint Address: HUDSON, RR (reprint author), UNIV CALIF IRVINE, DEPT ECOL & EVOLUT BIOL, IRVINE, CA 92717 USA |
Addresses:
1. UNIV CALIF BERKELEY, DEPT INTEGRAT BIOL, BERKELEY, CA 94720 USA
2. UNIV ARIZONA, DEPT ECOL & EVOLUT BIOL, TUCSON, AZ 85721 USA |
| Publisher: GENETICS, 428 EAST PRESTON ST, BALTIMORE, MD 21202 |
| Subject Category: Genetics & Heredity |
| IDS Number: JQ146 |
| ISSN: 0016-6731 |
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