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| ADHESION MOLECULE EXPRESSION IN POLYMORPHIC LIGHT ERUPTION |
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| Author(s): NORRIS PG, BARKER JNWN, ALLEN MH, LEIFERMAN KM, MACDONALD DM, HASKARD DO, HAWK JLM |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 99 Issue: 4 Pages: 504-508 Published: OCT 1992 |
| Times Cited: 33 References: 33 |
| Abstract: Endothelial leukocyte adhesion molecule-1 (ELAM-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are cytokine-regulated cell-surface leukocyte adhesion molecules. We have investigated the in vivo kinetics and pattern of expression of these adhesion molecules in relation to tissue accumulation of leukocytes in the photodermatosis, polymorphic light. eruption (PMLE), which is characterized by dense perivascular leukocytic infiltration. Immunohistology was performed on biopsies taken at varying time points from PMLE lesions induced in 11 subjects by suberythemal solar simulated irradiation. Vascular endothelial ELAM-1 expression was first observed at 5 h, maximal at 24 to 72 h, and remained elevated at 6 d. VCAM-1, minimally expressed in control skin, was induced above background levels on endothelium and some perivascular cells after 24 h and maintained at 6 d. Endothelial cell ICAM-1 expression was increased above control levels at 72 h and 6 d. Keratinocyte ICAM-1 expression, most marked overlying areas of dermal leukocytic infiltration, began at 5 h and was strong at 72 h and 6 d. In addition to lymphocytes, significant numbers of neutrophils but not eosinophils were detected in the dermal leukocytic infiltrate that appeared at 5 h and persisted at 6 d. The pattern of adhesion molecule expression that we have observed is similar to that seen in normal skin during a delayed hypersensitivity reaction. These observations support an immunologic basis for PMLE. |
| Document Type: Note |
| Language: English |
| Reprint Address: NORRIS, PG (reprint author), ST THOMAS HOSP, INST DERMATOL, PHOTOBIOL UNIT, 11TH FLOOR, N WING, LONDON SE1 7EH, ENGLAND |
Addresses:
1. GUYS HOSP, DEPT DERMATOL, LONDON SE1 9RT, ENGLAND
2. GUYS HOSP, DEPT RHEUMATOL, LONDON SE1 9RT, ENGLAND
3. MAYO CLIN & MAYO FDN, DEPT DERMATOL, ROCHESTER, MN 55905 USA |
| Publisher: BLACKWELL SCIENCE INC, 350 MAIN ST, MALDEN, MA 02148 |
| Subject Category: Dermatology |
| IDS Number: JR164 |
| ISSN: 0022-202X |
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