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| EVOLUTION OF SEX DETERMINATION AND THE Y-CHROMOSOME - SRY-RELATED SEQUENCES IN MARSUPIALS |
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| Author(s): FOSTER JW, BRENNAN FE, HAMPIKIAN GK, GOODFELLOW PN, SINCLAIR AH, LOVELLBADGE R, SELWOOD L, RENFREE MB, COOPER DW, GRAVES JAM |
| Source: NATURE Volume: 359 Issue: 6395 Pages: 531-533 Published: OCT 8 1992 |
| Times Cited: 148 References: 20 |
| Abstract: IN mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome1,2. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man3-5 and mouse6,7. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues8, are the first genes to be identified on the marsupial Y chromosome. |
| Document Type: Article |
| Language: English |
Addresses:
1. LA TROBE UNIV, DEPT GENET & HUMAN VARIAT, BUNDOORA, VIC 3083 AUSTRALIA
2. IMPERIAL CANC RES FUND, HUMAN MOLEC GENET LAB, LONDON WC2A 3PX, ENGLAND
3. NATL INST MED RES, MRC, EUKARYOT MOLEC GENET LAB, LONDON NW7 1AA, ENGLAND
4. LA TROBE UNIV, DEPT ZOOL, BUNDOORA, VIC 3083 AUSTRALIA
5. UNIV MELBOURNE, DEPT ZOOL, PARKVILLE, VIC 3052 AUSTRALIA
6. MACQUARIE UNIV, SCH BIOL SCI, N RYDE, NSW 2109 AUSTRALIA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JR859 |
| ISSN: 0028-0836 |
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