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| APOPTOTIC CELL-DEATH INDUCED BY C-MYC IS INHIBITED BY BCL-2 |
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| Author(s): BISSONNETTE RP, ECHEVERRI F, MAHBOUBI A, GREEN DR |
| Source: NATURE Volume: 359 Issue: 6395 Pages: 552-554 Published: OCT 8 1992 |
| Times Cited: 877 References: 29 |
| Abstract: APOPTOSIS is a form of physiological cell death, characterized by chromatin condensation, cytoplasmic blebbing and DNA fragmentation1, which often depends on RNA and protein synthesis by the dying cell2-4. The c-myc proto-oncogene, usually implicated in cell transformation, differentiation and cell-cycle progression5-9 also has a central role in some forms of apoptosis10-13. These opposing roles of myc in cell growth and death require that other gene products dictate the outcome of c-Myc expression on a cell. A candidate for such a modifying gene is bcl-2, whose product prolongs cell survival14-16 and blocks apoptosis in some systems17-21. Here we demonstrate that Bcl-2 prevents apoptotic death induced by c-Myc, provide a mechanism whereby cells can express c-Myc without undergoing apoptosis, and give a possible explanation for the ability of Bcl-2 to synergize with c-Myc in cell transformation21-23. |
| Document Type: Article |
| Language: English |
| Reprint Address: BISSONNETTE, RP (reprint author), LA JOLLA INST ALLERGY & IMMUNOL, DIV CELLULAR IMMUNOL, 11149 N TORREY PINES RD, LA JOLLA, CA 92037 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JR859 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |