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| COOPERATIVE INTERACTION BETWEEN C-MYC AND BCL-2 PROTOONCOGENES |
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| Author(s): FANIDI A, HARRINGTON EA, EVAN GI |
| Source: NATURE Volume: 359 Issue: 6395 Pages: 554-556 Published: OCT 8 1992 |
| Times Cited: 672 References: 16 |
| Abstract: THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene in tumour progression1. The mechanism of synergy is unclear but bcl-2 expression inhibits apoptosis2-6, a property presumably pertinent to its proto-oncogenic mode of action4. We have shown that the c-myc gene is a potent inducer of apoptosis, in addition to its established role in mitogenesis7. Here we show that expression of the bcl-2 protein, Bcl-2, specifically abrogates c-myc-induced apoptosis without affecting the c-myc mitogenic function. This provides a novel mechanism for oncogene cooperation, of potential importance both in carcinogenesis and in the evolution of drug resistance in tumours. |
| Document Type: Article |
| Language: English |
Addresses:
1. IMPERIAL CANC RES FUND, BIOCHEM CELL NUCLEUS LAB, 44 LINCOLNS INN FIELDS, LONDON WC2A 3PX, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JR859 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |