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| RECENT DEVELOPMENTS IN THE BIOLOGY OF DYSTROPHIN AND RELATED MOLECULES |
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| Author(s): KARPATI G |
| Source: CURRENT OPINION IN NEUROLOGY AND NEUROSURGERY Volume: 5 Issue: 5 Pages: 615-621 Published: OCT 1992 |
| Times Cited: 4 References: 34 |
| Abstract: Important progress in the understanding of various aspects of dystrophin biology continued during the past year. This relates to basic biochemistry, isoforms, subcellular localization in skeletal muscle, regional distribution in brain, physiological role, abnormalities caused by gene mutations and nuclear domain characteristics. Major progress has also taken place in the characterization of the dystrophin-associated glycoprotein (DAG) complex and in the understanding of its role in anchoring dystrophin to the plasmalemma and providing a link to the extracellular matrix. Characterization of the human chromosome-6-related analogue of dystrophin led to the discovery that in Duchenne muscular dystrophy (DMD) this molecule is expressed diffusely at the muscle cell surface and could, in part, compensate for the dystrophin deficiency of DMD. |
| Document Type: Article |
| Language: English |
| Reprint Address: KARPATI, G (reprint author), MCGILL UNIV, MONTREAL NEUROL INST, NEUROMUSCULAR RES GRP, 3801 UNIV ST, MONTREAL H3A 2B4, QUEBEC CANADA |
| Publisher: CURRENT SCIENCE LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Neurosciences |
| IDS Number: JT205 |
| ISSN: 0951-7383 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |