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| TREATMENT OF REFRACTORY FAMILIAL HYPERCHOLESTEROLEMIA BY LOW-DENSITY-LIPOPROTEIN APHERESIS USING AN AUTOMATED DEXTRAN SULFATE CELLULOSE ADSORPTION SYSTEM |
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| Author(s): GORDON BR, KELSEY SF, BILHEIMER DW, BROWN DC, DAU PC, GOTTO AM, ILLINGWORTH DR, JONES PH, LEITMAN SF, PRIHODA JS, STEIN EA, STERN TN, ZAVORAL JH, ZWIENER RJ |
| Source: AMERICAN JOURNAL OF CARDIOLOGY Volume: 70 Issue: 11 Pages: 1010-1016 Published: OCT 15 1992 |
| Times Cited: 62 References: 40 |
| Abstract: A subgroup of patients with familial hypercholesterolemia (FH) respond inadequately to standard diet and drug therapy, and are therefore at high risk for the premature development or progression of coronary artery disease This study evaluated low-density lipoprotein (LDL) cholesterol and protein (a) removal in a multicenter, controlled trial with a new LDL apheresis procedure (Liposorber(R) LA-15 System). The study comprised patients with FH who had not responded adequately to diet and maximal drug therapy, There were 54 patients with heterozygous FH (45 randomized to treatment and 9 control subjects) and 10 with homozygous FH (all of whom received LDL apheresis). The study included three 6-week treatment phases and a 4-week rebound phase. Treatments were administered at 7- to 14-day intervals. Mean acute reductions in LDL cholesterol were 76% in heterozygous FH patients and 81% in homozygous ones. Time-averaged levels of LDL cholesterol were reduced 41% (243 to 143 mg/dl) in heterozygous FH patients and 53% (447 to 210 mg/dl) in homozygous ones. The substantial acute. reduction of lipoprotein (a) (means. 65%, heterozygous FH; 68%, homozygous FH) has not been reported with other therapies. The Liposorber LA-15 System represents an important therapeutic option in FH patients who respond inadequately diet and drug therapy. |
| Document Type: Article |
| Language: English |
Addresses:
1. CORNELL UNIV, MED CTR, NEW YORK HOSP, ROGOSIN INST, NEW YORK, NY 10021 USA |
| Publisher: EXCERPTA MEDICA INC, 245 WEST 17TH STREET, NEW YORK, NY 10011 |
| Subject Category: Cardiac & Cardiovascular Systems |
| IDS Number: JT347 |
| ISSN: 0002-9149 |
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