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| GEOGRAPHIC ORIGIN OF THE Y-CHROMOSOMES IN OLD INBRED STRAINS OF MICE |
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| Author(s): TUCKER PK, LEE BK, LUNDRIGAN BL, EICHER EM |
| Source: MAMMALIAN GENOME Volume: 3 Issue: 5 Pages: 254-261 Published: 1992 |
| Times Cited: 57 References: 47 |
| Abstract: Six distinct Y Chromosomes (Chr) were identified among 39 standard inbred strains of mice with five probes that identified Y Chr-specific restriction fragments on Southern blots. Three Y Chr types, distributed among 31 strains, were of Asian Mus musculus origin. The remaining three Y Chr types, distributed among eight strains, were of M. domesticus origin. The Asian source of the M. musculus Y Chr was confirmed by determining the DNA sequence of 221 bp from an open reading frame within the Sry (sex determining region Y) gene (Gubbay et al., Nature 346: 245-250, 1990) in three inbred strains (C57BL/6J, AKR/J, and SWR/J) and comparing the sequence to the homologous sequences derived from wild caught European and Asian M. musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains. |
| Document Type: Article |
| Language: English |
Addresses:
1. JACKSON LAB, BAR HARBOR, ME 04609 USA
2. UNIV MICHIGAN, MUSEUM ZOOL, ANN ARBOR, MI 48109 USA
3. UNIV MICHIGAN, DEPT BIOL, ANN ARBOR, MI 48109 USA |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 |
| Subject Category: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity |
| IDS Number: JT434 |
| ISSN: 0938-8990 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |