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| MICE DEVELOP NORMALLY WITHOUT TENASCIN |
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| Author(s): SAGA Y, YAGI T, IKAWA Y, SAKAKURA T, AIZAWA S |
| Source: GENES & DEVELOPMENT Volume: 6 Issue: 10 Pages: 1821-1831 Published: OCT 1992 |
| Times Cited: 448 References: 58 |
| Abstract: Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena. To directly assess the function of tenascin in vivo, we generated mutant mice in which the tenascin gene was nully disrupted by replacing it with the lacZ gene. In mutant mice, lacZ was expressed in place of tenascin, and no tenascin product was detected. Homozygous mutant mice were, however, obtained in accordance with Mendelian laws, and both females and males produced offspring normally. No anatomical or histological abnormalities were detected in any tissues, and no major changes were observed in distribution of fibronectin, laminin, collagen, and proteoglycan. The existence of these mutant mice, lacking tenascin yet phenotypically normal, casts doubt on the theory that tenascin plays and essential role in normal development. |
| Document Type: Article |
| Language: English |
| Reprint Address: SAGA, Y (reprint author), INST PHYS & CHEM RES, TSUKUBA LIFE SCI CTR, CELL BIOL LAB, TSUKUBA, IBARAKI 305 JAPAN |
Addresses:
1. INST PHYS & CHEM RES, TSUKUBA LIFE SCI CTR, MOLEC ONCOL LAB, TSUKUBA, IBARAKI 305 JAPAN |
| Publisher: COLD SPRING HARBOR LAB PRESS, 1 BUNGTOWN RD, PLAINVIEW, NY 11724 |
| Subject Category: Cell Biology; Developmental Biology; Genetics & Heredity |
| IDS Number: JT979 |
| ISSN: 0890-9369 |
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