| | |  | | | | Record from Web of Science® | | | | | | |
| MULTIPLICITY GENERATES DIVERSITY IN THE RETINOIC ACID SIGNALING PATHWAYS |
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| Author(s): LEID M, KASTNER P, CHAMBON P |
| Source: TRENDS IN BIOCHEMICAL SCIENCES Volume: 17 Issue: 10 Pages: 427-433 Published: OCT 1992 |
| Times Cited: 778 References: 56 |
| Abstract: Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric interactions between two families of nuclear retinoic acid receptors, and between nuclear retinoic acid receptors and other members of the nuclear receptor superfamily. Thus, a complex array of combinatorial effects is beginning to emerge which may account for the pleiotropic effects of retinoids. |
| Document Type: Article |
| Language: English |
| Reprint Address: LEID, M (reprint author), FAC MED STRASBOURG, INST CHIM BIOL, GENET MOLEC EUCAROYTES LAB, CNRS, BIOL MOLEC & GENIE GENET U184, F-67085 STRASBOURG, FRANCE |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: JU181 |
| ISSN: 0968-0004 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |