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| SEVERE HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS IN APOLIPOPROTEIN-E-DEFICIENT MICE CREATED BY HOMOLOGOUS RECOMBINATION IN ES CELLS |
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| Author(s): PLUMP AS, SMITH JD, HAYEK T, AALTOSETALA K, WALSH A, VERSTUYFT JG, RUBIN EM, BRESLOW JL |
| Source: CELL Volume: 71 Issue: 2 Pages: 343-353 Published: OCT 16 1992 |
| Times Cited: 1,196 References: 43 |
| Abstract: apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when challenged with a high fat Western-type diet, these animals have plasma cholesterol levels of 1821 mg/dl compared with 132 mg/dl in controls. This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries. apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis. |
| Document Type: Article |
| Language: English |
| Reprint Address: PLUMP, AS (reprint author), ROCKEFELLER UNIV, BIOCHEM GENET & METAB LAB, NEW YORK, NY 10021 USA |
Addresses:
1. LAWRENCE BERKELEY LAB, DIV LIFE SCI, BERKELEY, CA 94720 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: JU395 |
| ISSN: 0092-8674 |
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