| DISCORDANT XENOGRAFT REJECTION IN AN ANTIBODY-FREE MODEL |
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| Author(s): JOHNSTON PS, WANG MW, LIM SML, WRIGHT LJ, WHITE DJG |
| Source: TRANSPLANTATION Volume: 54 Issue: 4 Pages: 573-576 Published: OCT 1992 |
| Times Cited: 55 References: 20 |
| Abstract: Newborn pigs prevented from suckling colostrum were shown to have less than 0.05 mug/ml total immunoglobulin present in their serum. Rabbit heart xenografts transplanted heterotopically into the neck of such pigs were hyperacutely rejected, with a mean survival time of 92+/-14 min (mean+/-SD). Pigs which had been allowed to suckle and whose serum contained 10-15 mg/ml maternal immunoglobulin hyperacutely rejected rabbit heart xenografts in 109+/-62 min. Histological studies showed no Ig binding but complement component 3 (C3) binding to rabbit hearts placed in immunoglobulin-negative pigs. Prolongation of rabbit heart xenograft survival was achieved by administering cobra venom factor (1 mg/kg) to the pigs pretransplant. These data show hyperacute xenograft rejection in the absence of antibody and suggest that its cause is activation of complement by the alternative pathway. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CAMBRIDGE, ADDENBROOKES HOSP, DEPT SURG, HILLS RD, CAMBRIDGE CB2 2QQ, ENGLAND |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Immunology; Surgery; Transplantation |
| IDS Number: JU603 |
| ISSN: 0041-1337 |