| | |  | | | | Record from Web of Science® | | | | | | |
| TARGETED DISRUPTION OF THE MOUSE TRANSFORMING GROWTH FACTOR-BETA-1 GENE RESULTS IN MULTIFOCAL INFLAMMATORY DISEASE |
|
|
| Author(s): SHULL MM, ORMSBY I, KIER AB, PAWLOWSKI S, DIEBOLD RJ, YIN MY, ALLEN R, SIDMAN C, PROETZEL G, CALVIN D, ANNUNZIATA N, DOETSCHMAN T |
| Source: NATURE Volume: 359 Issue: 6397 Pages: 693-699 Published: OCT 22 1992 |
| Times Cited: 1,661 References: 52 |
| Abstract: Transforming growth factor-beta1 (TGF-beta1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions. |
| Document Type: Article |
| Language: English |
| Reprint Address: SHULL, MM (reprint author), UNIV CINCINNATI, COLL MED, DEPT MOLEC GENET BIOCHEM & MICROBIOL, CINCINNATI, OH 45267 USA |
Addresses:
1. UNIV CINCINNATI, COLL MED, DEPT PATHOL & LAB MED, DIV COMPARAT PATHOL, CINCINNATI, OH 45267 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JU650 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |