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| GENETIC-LINKAGE EVIDENCE FOR A FAMILIAL ALZHEIMERS-DISEASE LOCUS ON CHROMOSOME-14 |
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| Author(s): SCHELLENBERG GD, BIRD TD, WIJSMAN EM, ORR HT, ANDERSON L, NEMENS E, WHITE JA, BONNYCASTLE L, WEBER JL, ALONSO ME, POTTER H, HESTON LL, MARTIN GM |
| Source: SCIENCE Volume: 258 Issue: 5082 Pages: 668-671 Published: OCT 23 1992 |
| Times Cited: 672 References: 55 |
| Abstract: Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Z(max) of 9.15 (theta = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (theta = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Z(max) = 5.94, theta = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14. |
| Document Type: Article |
| Language: English |
| Reprint Address: SCHELLENBERG, GD (reprint author), UNIV WASHINGTON, DEPT MED, DIV NEUROL, SEATTLE, WA 98195 USA |
Addresses:
1. VET AFFAIRS MED CTR, DIV NEUROL, SEATTLE, WA 98108 USA
2. UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA
3. MARSHFIELD MED RES FDN, MARSHFIELD, WI 54449 USA
4. NATL INST NEUROL & NEUROSURG, MEXICO CITY, MEXICO
5. WASHINGTON INST MENTAL ILLNESS RES & TRAINING, DEPT PSYCHIAT, STEILACOOM, WA 98494 USA
6. HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA
7. UNIV MINNESOTA, DEPT LAB MED & PATHOL, MINNEAPOLIS, MN 55455 USA
8. UNIV MINNESOTA, INST HUMAN GENET, MINNEAPOLIS, MN 55455 USA
9. UNIV MINNESOTA, DEPT PSYCHIAT, MINNEAPOLIS, MN 55455 USA
10. UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JU745 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |