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| INTERLEUKIN-4 IS LOCALIZED TO AND RELEASED BY HUMAN MAST-CELLS |
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| Author(s): BRADDING P, FEATHER IH, HOWARTH PH, MUELLER R, ROBERTS JA, BRITTEN K, BEWS JPA, HUNT TC, OKAYAMA Y, HEUSSER CH, BULLOCK GR, CHURCH MK, HOLGATE ST |
| Source: JOURNAL OF EXPERIMENTAL MEDICINE Volume: 176 Issue: 5 Pages: 1381-1386 Published: NOV 1 1992 |
| Times Cited: 492 References: 28 |
| Abstract: Recent attention has focused on the T helper type 2 (Th2) lymphocyte as a source of interleukin 4 (IL-4) in allergic disease. However, Th2 cells themselves require a pulse of IL-4 to initiate this synthesis. Here we provide immunohistochemical evidence of IL-4 localization to human mast cells of the skin and respiratory tract, and demonstrate that immunoglobulin E-dependent stimulation of purified human lung mast cells leads to the rapid release of IL-4 into the extracellular environment. We propose that mast cell activation in an allergic response provides a rapid and local pulse of IL-4 into the local environment essential for the triggering of T lymphocytes into sustained IL-4 production and to initiate inflammatory cell accumulation and activation. |
| Document Type: Article |
| Language: English |
Addresses:
1. SOUTHAMPTON GEN HOSP, IMMUNOPHARMACOL GRP, SOUTHAMPTON SO9 4XY, HANTS ENGLAND
2. CIBA GEIGY AG, CH-4002 BASEL, SWITZERLAND |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Immunology; Medicine, Research & Experimental |
| IDS Number: JV012 |
| ISSN: 0022-1007 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |