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| EXPRESSION OF THE X-INACTIVATION-ASSOCIATED GENE XIST DURING SPERMATOGENESIS |
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| Author(s): SALIDO EC, YEN PH, MOHANDAS TK, SHAPIRO LJ |
| Source: NATURE GENETICS Volume: 2 Issue: 3 Pages: 196-199 Published: NOV 1992 |
| Times Cited: 104 References: 29 |
| Abstract: Mammalian X-chromosome inactivation is thought to be controlled by the X inactivation centre (XIC, X-controlling element -Xce- in mice). A human gene, XIST and its mouse counterpart, Xist, which map to the XIC/Xce, are expressed exclusively from inactive X chromosomes, suggesting their involvement in the process of X-inactivation. We now report the presence of Xist/XIST transcripts in newborn and adult mouse testes, and in human testicular tissue with normal spermatogenesis, but not in the testes of patients who lack germ cells. Our results indicate that while the X chromosome in males is active in somatic cells, it undergoes inactivation during spermatogenesis. |
| Document Type: Article |
| Language: English |
| Reprint Address: SALIDO, EC (reprint author), UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, SCH MED, HOWARD HUGHES MED INST, TORRANCE, CA 90509 USA |
Addresses:
1. UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, SCH MED, DEPT PEDIAT, TORRANCE, CA 90509 USA
2. UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, SCH MED, DEPT BIOL CHEM, TORRANCE, CA 90509 USA
3. UNIV LA LAGUNA, SCH MED, DEPT PATHOL, E-38071 TENERIFE, SPAIN |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: JW165 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |