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| FERTILITY IN MICE REQUIRES X-Y PAIRING AND A Y-CHROMOSOMAL SPERMIOGENESIS GENE-MAPPING TO THE LONG ARM |
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| Author(s): BURGOYNE PS, MAHADEVAIAH SK, SUTCLIFFE MJ, PALMER SJ |
| Source: CELL Volume: 71 Issue: 3 Pages: 391-398 Published: OCT 30 1992 |
| Times Cited: 100 References: 39 |
| Abstract: There is accumulating evidence that the mammalian Y chromosome, in addition to its testis-determining function, may have other male limited functions, particularly in spermatogenesis. We have previously shown that the short arm of the mouse Y carries information needed for spermatogonial proliferation. This information, together with the testis-determining gene Sry, is contained within the Y-derived sex reversal factor Sxr(a). XO males carrying a copy of Sxr(a) attached to the X chromosome are nevertheless sterile owing to an almost complete arrest during the meiotic metaphase stages. Here we show that this meiotic block can be overcome by providing a meiotic pairing partner (with no Y-specific DNA) for the XSxr(a) chromosome. However, this does not restore fertility because the sperm produced all have abnormal heads. It is concluded that the Y-specific region of the mouse Y chromosome long arm includes information essential for the normal development of the sperm head. |
| Document Type: Article |
| Language: English |
| Reprint Address: BURGOYNE, PS (reprint author), MRC, MAMMALIAN DEV UNIT, WOLFSON HOUSE, 4 STEPHENSON WAY, LONDON NW1 2HE, ENGLAND |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: JW435 |
| ISSN: 0092-8674 |
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