| | |  | | | | Record from Web of Science® | | | | | | |
| SELECTINS - INTERPRETERS OF CELL-SPECIFIC CARBOHYDRATE INFORMATION DURING INFLAMMATION |
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| Author(s): LASKY LA |
| Source: SCIENCE Volume: 258 Issue: 5084 Pages: 964-969 Published: NOV 6 1992 |
| Times Cited: 1,109 References: 90 |
| Abstract: Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated. |
| Document Type: Article |
| Language: English |
| Reprint Address: LASKY, LA (reprint author), GENENTECH INC, DEPT IMMUNOL, S SAN FRANCISCO, CA 94080 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JW796 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |