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| EXPRESSION OF C-KIT RECEPTOR IN NORMAL AND TRANSFORMED HUMAN NONLYMPHOID TISSUES |
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| Author(s): NATALI PG, NICOTRA MR, SURES I, SANTORO E, BIGOTTI A, ULLRICH A |
| Source: CANCER RESEARCH Volume: 52 Issue: 22 Pages: 6139-6143 Published: NOV 15 1992 |
| Times Cited: 155 References: 34 |
| Abstract: The protooncogene c-kit encodes a tyrosine kinase with a molecular weight of 145,000, highly related to the platelet derived growth factor/colony stimulating factor receptors. Mutations of the murine gene result in impairment of hematopoiesis, gametogenesis, and of the melanocyte cell lineage. In order to elucidate c-kit functions in development and oncogenesis we have analyzed immunohistochemically its expression in human normal and transformed nonlymphoid tissues. The receptor has been detected in spermatogonia, melanocytes, and unexpectedly, in astrocytes, renal tubules, parotid cells, thyrocytes, and breast epithelium. While the gene product is expressed in seminoma, lung tumors, and melanoma of low invasiveness, no detectable levels have been detected in thyroid and breast carcinomas, astrocytomas, and invasive melanomas. In breast tumors these findings were confirmed by paired, Northern blot Analysis of RNA preparations from normal and transformed tissue. The present results demonstrate that the c-kit receptor plays a role in the development of a larger spectrum of cell lineages. Furthermore, on the basis of the transformation associated changes, we speculate that, while in some cell types, c-kit expression positively regulates mitogenesis and is selected for in neoplastic transformation, in other tissues the c-kit pathway, is involved in morphogenesis and differentiation and is, therefore, negatively selected in the course of tumor progression. |
| Document Type: Article |
| Language: English |
| Reprint Address: NATALI, PG (reprint author), REGINA ELENA INST CANC RES, IMMUNOL LAB, VIA MESSI DORO 156, I-00158 ROME, ITALY |
Addresses:
1. CNR, INST BIOMED TECHNOL, ROME, ITALY
2. MAX PLANCK INST BIOCHEM, DEPT MOLEC BIOL, W-8033 MARTINSRIED, GERMANY |
| Publisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA |
| Subject Category: Oncology |
| IDS Number: JX754 |
| ISSN: 0008-5472 |
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