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| ADHESION MOLECULES AND TUMOR-CELL INTERACTION WITH ENDOTHELIUM AND SUBENDOTHELIAL MATRIX |
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| Author(s): HONN KV, TANG DG |
| Source: CANCER AND METASTASIS REVIEWS Volume: 11 Issue: 3-4 Pages: 353-375 Published: NOV 1992 |
| Times Cited: 171 References: 167 |
| Abstract: Cancer metastasis poses the greatest challenge to the eradication of malignancy. The majority of clinical and experimental evidence indicates that metastasis is a non-random, organ-specific process. Tumor cell interaction with endothelium and subendothelial matrix constitutes the most crucial factor in determining the organ preference of metastasis. A plethora of cell surface adhesion molecules, which encompass four major families (i.e., integrins, cadherins, immunoglobulins and selectins) and many other unclassified molecules, mediate tumor-host interactions. Adhesion molecules and adhesion processes are involved in most, if not all, of the intermediate steps of the metastatic cascade. Decreased E-cadherin expression and increased CD44 expression are clearly correlated with the acquisition of the invasive capacity of primary tumor cells. Similarly, altered expression pattern of many other adhesion molecules such as upregulated expression of the laminin receptors and depressed expression of fibronectin receptors (alpha5beta1) appears to be involved in tumor cell invasion into the subendothelial matrix. Tumor cell-endothelium interactions involve several well-defined sequential steps that can be analyzed by the 'Docking and Locking' hypothesis at the molecular level. Tumor cell-matrix interactions are determined by the repertoire of adhesion receptors of tumor cells and the unique composition of organ-specific matrices. Our experimental data, together with others', suggest that the integrin alphaIIbbeta3 is one of the major players in these tumor-host interactions. Tumor-host interaction is a dynamic process which is constantly modulated by a host of factors including various cytokines, growth factors and arachidonate metabolites such as 12(S)-HETE. Delineation of the molecular mechanisms of tumor-host interactions may provide additional means to intervene in the metastatic process. |
| Document Type: Review |
| Language: English |
| Reprint Address: HONN, KV (reprint author), WAYNE STATE UNIV, DEPT RADIAT ONCOL, DIV CANC BIOL, 431 CHEM BLDG, DETROIT, MI 48202 USA |
Addresses:
1. WAYNE STATE UNIV, DEPT CHEM, DETROIT, MI 48202 USA |
| Publisher: KLUWER ACADEMIC PUBL, SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS |
| Subject Category: Oncology |
| IDS Number: JX880 |
| ISSN: 0167-7659 |
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