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| RESPONSES OF EMBRYONIC XENOPUS CELLS TO ACTIVIN AND FGF ARE SEPARATED BY MULTIPLE DOSE THRESHOLDS AND CORRESPOND TO DISTINCT AXES OF THE MESODERM |
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| Author(s): GREEN JBA, NEW HV, SMITH JC |
| Source: CELL Volume: 71 Issue: 5 Pages: 731-739 Published: NOV 27 1992 |
| Times Cited: 375 References: 64 |
| Abstract: The potent mesoderm-inducing factors activin and FGF are present as maternally synthesized proteins in embryos of X. laevis. We show that activin can act on explanted blastomeres to induce at least five different cell states ranging from posterolateral mesoderm to dorsoanterior organizer mesoderm. Each state is induced in a narrow dose range bounded by sharp thresholds. By contrast, FGF induces only posterolateral markers and does so over relatively broad dose ranges. FGF can modulate the actions of activin, potentiating them and broadening the threshold-bounded dose windows. Our results indicate that orthogonal gradients of activin and FGF would be sufficient to specify the main elements of the body plan. |
| Document Type: Article |
| Language: English |
| Reprint Address: GREEN, JBA (reprint author), NATL INST MED RES, OPHTHALMOL LAB, RIDGEWAY, MILL HILL, LONDON NW7 1AA, ENGLAND |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: JZ633 |
| ISSN: 0092-8674 |
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