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| MOLECULAR ANALYSIS OF THE ASSOCIATION OF HLA-B53 AND RESISTANCE TO SEVERE MALARIA |
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| Author(s): HILL AVS, ELVIN J, WILLIS AC, AIDOO M, ALLSOPP CEM, GOTCH FM, GAO XM, TAKIGUCHI M, GREENWOOD BM, TOWNSEND ARM, MCMICHAEL AJ, WHITTLE HC |
| Source: NATURE Volume: 360 Issue: 6403 Pages: 434-439 Published: DEC 3 1992 |
| Times Cited: 517 References: 65 |
| Abstract: The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component. |
| Document Type: Article |
| Language: English |
| Reprint Address: HILL, AVS (reprint author), UNIV OXFORD, JOHN RADCLIFFE HOSP, INST MOLEC MED, MOLEC IMMUNOL GRP, OXFORD OX3 9DU, ENGLAND |
Addresses:
1. UNIV OXFORD, DEPT BIOCHEM, MRC, IMMUNOCHEM UNIT, OXFORD OX1 3QU, ENGLAND
2. MRC LABS, BANJUL, SENEGAMBIA
3. UNIV TOKYO, INST MED SCI, MINAMI KU, TOKYO 108, JAPAN |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KA797 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |