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| MOSAICISM FOR A SPECIFIC SOMATIC MITOCHONDRIAL-DNA MUTATION IN ADULT HUMAN BRAIN |
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| Author(s): SOONG NW, HINTON DR, CORTOPASSI G, ARNHEIM N |
| Source: NATURE GENETICS Volume: 2 Issue: 4 Pages: 318-323 Published: DEC 1992 |
| Times Cited: 243 References: 44 |
| Abstract: The levels of a specific mitochondrial DNA deletion (mtDNA4977 measured in 12 brain regions of 6 normal adults 39 to 82 years old exhibited striking variation among anatomical locations. Comparisons of the same region among individuals showed an increase of mtDNA4977 With age. The three regions with the highest levels, caudate, putamen and substantia nigra, are characterized by a high dopamine metabolism. The breakdown of dopamine by mitochondrial MAO produces H2O2 which can lead to oxygen radical formation. We suggest that mtDNA4977 may be the "tip of the iceberg" of the spectrum of somatic mutations produced by oxidative damage. |
| Document Type: Article |
| Language: English |
| Reprint Address: SOONG, NW (reprint author), UNIV SO CALIF, MOLEC BIOL SECT, LOS ANGELES, CA 90089 USA |
Addresses:
1. USC, SCH MED, DEPT PATHOL, LOS ANGELES, CA 90033 USA
2. UNIV SO CALIF, INST TOXICOL, LOS ANGELES, CA 90033 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: KB495 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |