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| PERSPECTIVES ON HOLOPROSENCEPHALY .2. CENTRAL-NERVOUS-SYSTEM, CRANIOFACIAL ANATOMY, SYNDROME COMMENTARY, DIAGNOSTIC-APPROACH, AND EXPERIMENTAL STUDIES |
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| Author(s): COHEN MM, SULIK KK |
| Source: JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY Volume: 12 Issue: 4 Pages: 196-244 Published: OCT-DEC 1992 |
| Times Cited: 98 References: 315 |
| Abstract: This paper presents an updated analytic review of the holoprosencephalic disorders. Central nervous system findings and craniofacial anatomy are discussed in depth. Associated anomalies and syndromes are updated with a syndrome commentary that attempts to separate durable syndromes from associated anomalies and spurious entities. The differential diagnosis of various conditions that may simulate the holoprosencephalic disorders is also discussed. Various experimental approaches to holoprosencephaly are reviewed, indicating that holoprosencephaly appears to be both etiologically and pathogenetically heterogeneous. |
| Document Type: Review |
| Language: English |
| Reprint Address: COHEN, MM (reprint author), DALHOUSIE UNIV, FAC DENT, DEPT ORAL BIOL, HALIFAX B3H 3J5, NS CANADA |
Addresses:
1. DALHOUSIE UNIV, FAC MED, DEPT PEDIAT, HALIFAX B3H 4H2, NS CANADA
2. UNIV N CAROLINA, SCH MED, DEPT ANAT, CHAPEL HILL, NC 27514 USA
3. UNIV N CAROLINA, SCH DENT, DENT RES CTR, CHAPEL HILL, NC 27514 USA |
| Publisher: MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK |
| Subject Category: Anatomy & Morphology; Developmental Biology; Genetics & Heredity |
| IDS Number: KB868 |
| ISSN: 0270-4145 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |