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| ALLELIC LOSS FROM CHROMOSOME-11 IN PARATHYROID TUMORS |
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| Author(s): FRIEDMAN E, DEMARCO L, GEJMAN PV, NORTON JA, BALE AE, AURBACH GD, SPIEGEL AM, MARX SJ |
| Source: CANCER RESEARCH Volume: 52 Issue: 24 Pages: 6804-6809 Published: DEC 15 1992 |
| Times Cited: 96 References: 37 |
| Abstract: Parathyroid tumors may occur in a sporadic fashion or, more rarely, as part of a familial syndrome (such as familial multiple endocrine neoplasia type I). The MENI gene has been mapped by linkage analysis to chromosome 11 at band q11-q13, and presumably acts as a tumor suppressor gene. In the present study, which is an extension of our previous studies, we examined 41 parathyroid tumors from patients with familial multiple endocrine neoplasia type I and 61 sporadic parathyroid tumors with markers on chromosome 11, to assess the extent of allelic loss in those tumors. Twenty-four of the MENI-associated tumors (58%) and 16 of the sporadic parathyroid tumors (26%) displayed allelic loss from chromosome 11. The region of overlap of the allelic losses in the MENI-associated tumors enables us to place the MENI gene between PGA centromerically and INT2 telomerically, a region spanning about 7.5 cM. Taken together with locus ordering by linkage analysis, this clearly localizes the MENI gene telomeric to the PGA locus. Our inability to detect allelic loss on chromosome 11 in some parathyroid tumors suggests the existence of other genes involved in the development and/or progression of this subgroup of presumably monoclonal tumors; or that localized events involving the 11q tumor suppressor gene have occurred in some parathyroid tumors whose detection is beyond the sensitivity of our analysis; or that at least some of the specimens analyzed were in fact primarily hyperplastic parathyroid tissue. |
| Document Type: Article |
| Language: English |
Addresses:
1. NIDDKD, MOLEC PATHOPHYSIOL BRANCH, BETHESDA, MD 20892 USA
2. NIDDKD, METAB DIS BRANCH, BETHESDA, MD 20892 USA
3. NIMH, CLIN NEUROGENET BRANCH, BETHESDA, MD 20892 USA
4. NCI, SURG BRANCH, BETHESDA, MD 20892 USA
5. YALE UNIV, SCH MED, DEPT HUMAN GENET, NEW HAVEN, CT 06510 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: KB979 |
| ISSN: 0008-5472 |
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