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| EXPRESSION OF THE PROTOONCOGENE BCL-2 IN THE PROSTATE AND ITS ASSOCIATION WITH EMERGENCE OF ANDROGEN-INDEPENDENT PROSTATE-CANCER |
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| Author(s): MCDONNELL TJ, TRONCOSO P, BRISBAY SM, LOGOTHETIS C, CHUNG LWK, HSIEH JT, TU SM, CAMPBELL ML |
| Source: CANCER RESEARCH Volume: 52 Issue: 24 Pages: 6940-6944 Published: DEC 15 1992 |
| Times Cited: 842 References: 19 |
| Abstract: The significance of apoptosis in relation to the development and progression of prostate cancer remains largely undefined. bcl-2 is an oncogene that functions by overriding apoptosis. bcl-2 expression was localized to the basal epithelial cells in the normal human prostate with the use of immunohistochemistry. Androgen-dependent and androgen-independent prostate carcinomas were evaluated immunohistochemically for bcl-2 expression. bcl-2 was undetectable in 13 of 19 cases of androgen-dependent cancers. In contrast, androgen-independent cancers displayed diffuse, high levels of bcl-2 staining (P < 0.01). In rats, steady-state levels of bcl-2 mRNA, assessed by S1 assays, reached maximum levels 10 days following castration. Addition of exogenous testosterone with, or without, flutamide demonstrated that the increased bcl-2 mRNA resulted from androgen ablation. Our findings indicate that bcl-2 expression is augmented following androgen ablation and is correlated with the progression of prostate cancer from androgen dependence to androgen independence. |
| Document Type: Note |
| Language: English |
| Reprint Address: MCDONNELL, TJ (reprint author), UNIV TEXAS, MD ANDERSON CANC CTR, DEPT MOLEC PATHOL, BOX 89, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA |
Addresses:
1. UNIV TEXAS, MD ANDERSON CANC CTR, DEPT PATHOL, HOUSTON, TX 77030 USA
2. UNIV TEXAS, MD ANDERSON CANC CTR, DEPT MED ONCOL, HOUSTON, TX 77030 USA
3. UNIV TEXAS, MD ANDERSON CANC CTR, DEPT UROL, HOUSTON, TX 77030 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: KB979 |
| ISSN: 0008-5472 |
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