| DO G-PROTEIN SUBUNITS ASSOCIATE VIA A 3-STRANDED COILED COIL |
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| Author(s): LUPAS AN, LUPAS JM, STOCK JB |
| Source: FEBS LETTERS Volume: 314 Issue: 2 Pages: 105-108 Published: DEC 14 1992 |
| Times Cited: 55 References: 26 |
| Abstract: We used a computer-based prediction algorithm to identify probable coiled-coil segments at the N-termini of G protein alpha, beta and gamma subunits. This result indicates that G protein trimers may form via a three-stranded coiled coil. Previous biochemical results had shown that the N-termini of alpha and beta are involved in subunit interactions. Here we present a structural model for the N-terminal domain of betagamma and a hypothesis for the reversible association of alpha to betagamma. |
| Document Type: Article |
| Language: English |
| Reprint Address: LUPAS, AN (reprint author), MAX PLANCK INST BIOCHEM, KLOPFERSPITZ 18A, W-8033 MARTINSRIED, GERMANY |
Addresses:
1. PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: KC064 |
| ISSN: 0014-5793 |