| | |  | | | | Record from Web of Science® | | | | | | |
| RETINOIDS SELECTIVE FOR RETINOID-X RECEPTOR RESPONSE PATHWAYS |
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| Author(s): LEHMANN JM, JONG L, FANJUL A, CAMERON JF, LU XP, HAEFNER P, DAWSON MI, PFAHL M |
| Source: SCIENCE Volume: 258 Issue: 5090 Pages: 1944-1946 Published: DEC 18 1992 |
| Times Cited: 305 References: 31 |
| Abstract: Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding and function. However, in the presence of 9-cis-retinoic acid, a ligand for both RARs and RXRs, RXRs can also form homodimers. A series of retinoids is reported that selectively activates RXR homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that both retinoid response pathways can be independently activated. |
| Document Type: Article |
| Language: English |
Addresses:
1. SRI INT, DIV LIFE SCI, MENLO PK, CA 94025 USA
2. LA JOLLA CANC RES FDN, CTR CANC, LA JOLLA, CA 92037 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KD088 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |