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| MOLECULAR CHARACTERIZATION OF THE MOUSE AGOUTI LOCUS |
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| Author(s): BULTMAN SJ, MICHAUD EJ, WOYCHIK RP |
| Source: CELL Volume: 71 Issue: 7 Pages: 1195-1204 Published: DEC 24 1992 |
| Times Cited: 483 References: 65 |
| Abstract: The agouti (a) locus acts within the microenvironment of the hair follicle to regulate coat color pigmentation in the mouse. We have characterized a gene encoding a novel 131 amino acid protein that we propose is the one gene associated with the agouti locus. This gene is normally expressed in a manner consistent with a locus function, and, more importantly, its structure and expression are affected by a number of representative alleles in the agouti dominance hierarchy. In addition, we found that the pleiotropic effects associated with the lethal yellow (A(y)) mutation, which include pronounced obesity, diabetes, and the development of neoplasms, are accompanied by deregulated overexpression of the agouti gene in numerous tissues of the adult animal. |
| Document Type: Article |
| Language: English |
| Reprint Address: BULTMAN, SJ (reprint author), OAK RIDGE NATL LAB, DIV BIOL, OAK RIDGE, TN 37831 USA |
Addresses:
1. UNIV TENNESSEE, SCH BIOMED SCI, DIV BIOL, OAK RIDGE NATL LAB, OAK RIDGE, TN 37831 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: KE604 |
| ISSN: 0092-8674 |
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