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| PAX-5 IS EXPRESSED AT THE MIDBRAIN-HINDBRAIN BOUNDARY DURING MOUSE DEVELOPMENT |
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| Author(s): ASANO M, GRUSS P |
| Source: MECHANISMS OF DEVELOPMENT Volume: 39 Issue: 1-2 Pages: 29-39 Published: NOV 1992 |
| Times Cited: 77 References: 50 |
| Abstract: The murine paired-box-containing gene 5, Pax-5, is highly homologous to two other Pax genes, Pax-2 and Pax-8. The expression pattern of Pax-5 during mouse embryogenesis was examined by in situ RNA hybridization and compared to those of Pax-2 and Pax-8. Beginning at day 9.5 postcoitum (p.c.), Pax-5 was expressed in the developing brain, predominantly at the midbrain-hindbrain boundary, and in the neural tube. While the neural tube expression pattern overlapped completely with Pax-2 and Pax-8, the expression pattern in the brain was only partially overlapping. Unlike Pax-2 and Pax-8, Pax-5 was not expressed in the developing excretory system, thyroid, eye or ear. Our data suggest that Pax-5 has a role in the development of the central nervous system. |
| Document Type: Article |
| Language: English |
| Reprint Address: ASANO, M (reprint author), MAX PLANCK INST BIOPHYS CHEM, DEPT MOLEC CELL BIOL, W-3400 GOTTINGEN, GERMANY |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Developmental Biology |
| IDS Number: KF554 |
| ISSN: 0925-4773 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |