| | |  | | | | Record from Web of Science® | | | | | | |
| EMPIRICAL ESTIMATES OF BONFERRONI CORRECTIONS FOR USE IN CHROMOSOME MAPPING STUDIES WITH THE BXD RECOMBINANT INBRED STRAINS |
|
|
| Author(s): BELKNAP JK |
| Source: BEHAVIOR GENETICS Volume: 22 Issue: 6 Pages: 677-684 Published: NOV 1992 |
| Times Cited: 47 References: 18 |
| Abstract: Most chromosome mapping efforts with the BXD recombinant inbred (RI) strains involve comparisons between a trait of interest and each of a large number of marker loci for evidence of linkage. Such multiple tests or comparisons greatly increase the Type I error rate compared to the single-test situation. Perhaps the most direct way to obtain multiple-test error rates is to employ a Bonferroni correction, where the single-test alpha is multiplied by the number of independent (nonredundant) comparisons (k) to yield a multiple-test alpha that protects against even one fortuitous association with any of the markers. Several empirical estimates of k are discussed for the published BXD marker set of 142 mapped loci and the newer unpublished marker set (October 1991) comprised of 352 marker loci. Reasonable estimates of k appear to be roughly 40 and 65 for these two marker sets, respectively. |
| Document Type: Article |
| Language: English |
| Reprint Address: BELKNAP, JK (reprint author), OREGON HLTH SCI UNIV, RES SERV 151W, VA MED CTR, PORTLAND, OR 97201 USA |
Addresses:
1. OREGON HLTH SCI UNIV, DEPT MED PSYCHOL, PORTLAND, OR 97201 USA |
| Publisher: PLENUM PUBL CORP, 233 SPRING ST, NEW YORK, NY 10013 |
| Subject Category: Behavioral Sciences; Genetics & Heredity; Psychology, Multidisciplinary |
| IDS Number: KK294 |
| ISSN: 0001-8244 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |