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| A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS |
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| Author(s): BLISS TVP, COLLINGRIDGE GL |
| Source: NATURE Volume: 361 Issue: 6407 Pages: 31-39 Published: JAN 7 1993 |
| Times Cited: 5,472 References: 174 |
| Abstract: Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength. |
| Document Type: Review |
| Language: English |
| Reprint Address: BLISS, TVP (reprint author), NATL INST MED RES, DIV NEUROPHYSIOL & NEUROPHARMACOL, MILL HILL, LONDON NW7 1AA, ENGLAND |
Addresses:
1. UNIV BIRMINGHAM, DEPT PHARMACOL, BIRMINGHAM B15 2TT, W MIDLANDS ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KF718 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |