| | |  | | | | Record from Web of Science® | | | | | | |
| THE GENE INVOLVED IN X-LINKED AGAMMAGLOBULINEMIA IS A MEMBER OF THE SRC FAMILY OF PROTEIN-TYROSINE KINASES |
|
|
| Author(s): VETRIE D, VORECHOVSKY I, SIDERAS P, HOLLAND J, DAVIES A, FLINTER F, HAMMARSTROM L, KINNON C, LEVINSKY R, BOBROW M, SMITH CIE, BENTLEY DR |
| Source: NATURE Volume: 361 Issue: 6409 Pages: 226-233 Published: JAN 21 1993 |
| Times Cited: 790 References: 62 |
| Abstract: X-linked agammaglobulinaemia (XLA) is a human immunodeficiency caused by failure of pre-B cells in the bone marrow to develop into circulating mature B cells. A novel gene has been isolated which maps to the XLA locus, is expressed in B cells, and shows mutations in families with the disorder. The gene is a member of the src family of proto-oncogenes which encode protein-tyrosine kinases. This is, to our knowledge, the first evidence that mutations in a src-related gene are involved in human genetic disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: VETRIE, D (reprint author), UMDS GUYS & ST THOMASS HOSP, DIV MED & MOLEC GENET, GUYS TOWER, LONDON SE1 9RT, ENGLAND |
Addresses:
1. KAROLINSKA INST, NOVUM, CTR BIOTECHNOL, S-14157 HUDDINGE, SWEDEN
2. UMEA UNIV, APPL CELL & MOLEC BIOL UNIT, S-90187 UMEA, SWEDEN
3. INST CHILD HLTH, MOLEC IMMUNOL UNIT, LONDON WC1N 1EH, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KH614 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |