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| ANTIBODIES AGAINST INTERCELLULAR-ADHESION MOLECULE-1 AND LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 PREVENT GLOMERULAR INJURY IN RAT EXPERIMENTAL CRESCENTIC GLOMERULONEPHRITIS |
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| Author(s): KAWASAKI K, YAOITA E, YAMAMOTO T, TAMATANI T, MIYASAKA M, KIHARA I |
| Source: JOURNAL OF IMMUNOLOGY Volume: 150 Issue: 3 Pages: 1074-1083 Published: FEB 1 1993 |
| Times Cited: 210 References: 44 |
| Abstract: The involvement of adhesion molecules in the glomerular accumulation of inflammatory cells and subsequent glomerular injury was examined in WKY rats with nephrotoxic serum nephritis. This model is characterized by early infiltration of CD8-positive NK cells, followed by influx of monocytes/macrophages into the glomeruli. At day 1 and later, up-regulated expression of intercellular adhesion molecule-1 (ICAM-1) was observed exclusively in the glomerular endothelial cells in association with the influx of CD8-positive cells and monocytes/macrophages. These cells expressed lymphocyte function-associated Ag-1 (LFA-1). Repeated injection of mAb against rat ICAM-1 or alpha-subunit of LFA-1 (LFA-1alpha) dose dependently prevented the development of proteinuria, the influx of these cells, and subsequent crescent formation in this nephrotoxic serum nephritis model. Furthermore, simultaneous administration of anti-ICAM-1 mAb and anti-LFA-1alpha mAb exerted additive protective effects against urinary protein excretion and crescentic glomerulonephritis. Binding of anti-GBM antibody to the glomeruli and production of circulating anti-rabbit IgG antibody were unaffected by injection of these mAb. These results indicate that adhesion of CD8-positive cells and monocytes to glomerular endothelial cells through the LFA-1/ICAM-1 pathway is crucial for the initiation and subsequent progression of nephrotoxic serum nephritis in WKY rats. |
| Document Type: Article |
| Language: English |
| Reprint Address: KAWASAKI, K (reprint author), NIIGATA UNIV, SCH MED, INST NEPHROL, DEPT PATHOL, ASAHIMACHI 1-757, NIIGATA 951, JAPAN |
Addresses:
1. TOKYO METROPOLITAN INST MED SCI, DEPT IMMUNOL, TOKYO 113, JAPAN |
| Publisher: AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Immunology |
| IDS Number: KJ095 |
| ISSN: 0022-1767 |
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