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| NEUTROPHIL ATTRACTANT ACTIVATION PROTEIN-1 (INTERLEUKIN-8) INDUCES INVITRO NEUTROPHIL MIGRATION BY HAPTOTACTIC MECHANISM |
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| Author(s): ROT A |
| Source: EUROPEAN JOURNAL OF IMMUNOLOGY Volume: 23 Issue: 1 Pages: 303-306 Published: JAN 1993 |
| Times Cited: 145 References: 19 |
| Abstract: The role of leukocyte migration induced by the substrate-bound attractants is obscured by the inability of standard methods for the study of leukocyte migration to dissociate chemotaxis and haptotaxis, migration in response to soluble and surface-bound gradients of attractants. Here we show that the gradient of neutrophil attractant/activation protein-1 (interleukin-8, NAP-1/IL-8) induces directed in vitro neutrophil migration when bound to the polycarbonate filter. In addition, we suggest that haptotaxis is responsible for neutrophil migration induced by NAP-1/IL-8 in standard Boyden-type chemotaxis assays and, in light of the ability of NAP-1/IL-8 to bind to the endothelial cell surface and the extracellular matrix, could also be of great significance in vivo. |
| Document Type: Note |
| Language: English |
| Reprint Address: ROT, A (reprint author), SANDOZ GMBH, BRUNNER STR 59, A-1235 VIENNA, AUSTRIA |
| Publisher: VCH PUBLISHERS INC, 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 |
| Subject Category: Immunology |
| IDS Number: KJ132 |
| ISSN: 0014-2980 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |