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| CNTF PROTECTION OF OLIGODENDROCYTES AGAINST NATURAL AND TUMOR NECROSIS FACTOR-INDUCED DEATH |
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| Author(s): LOUIS JC, MAGAL E, TAKAYAMA S, VARON S |
| Source: SCIENCE Volume: 259 Issue: 5095 Pages: 689-692 Published: JAN 29 1993 |
| Times Cited: 383 References: 65 |
| Abstract: A proportion of developing oligodendrocytes undergo natural cell death by apoptosis, and mature oligodendrocytes die, either by apoptosis or necrosis, in response to injurious signals such as cytotoxic cytokines and complement. Ciliary neurotrophic factor (CNTF), a trophic factor found in astrocytes in the central nervous system (CNS), promoted the survival and maturation of cultured oligodendrocytes. This trophic factor also protected oligodendrocytes from death induced by tumor necrosis factors (apoptosis) but not against complement (necrosis). These results suggest that CNTF functions in the survival of oligodendrocytes during development and may lead to therapeutic approaches for degenerative diseases of the CNS that involve oligodendrocyte destruction. |
| Document Type: Article |
| Language: English |
| Reprint Address: LOUIS, JC (reprint author), UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KJ688 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |