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| A MAJOR SUSCEPTIBILITY LOCUS TO MURINE LUNG CARCINOGENESIS MAPS ON CHROMOSOME-6 |
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| Author(s): GARIBOLDI M, MANENTI G, CANZIAN F, FALVELLA FS, RADICE MT, PIEROTTI MA, DELLAPORTA G, BINELLI G, DRAGANI TA |
| Source: NATURE GENETICS Volume: 3 Issue: 2 Pages: 132-136 Published: FEB 1993 |
| Times Cited: 115 References: 39 |
| Abstract: Lung tumours represent a major cause of death in humans, and although smoking represents the main pathogenetic factor, inheritance also plays a part. However, the identification of possible predisposing genetic factors is difficult, because of their low penetrance. We took advantage of murine strains that are genetically susceptible or resistant to lung tumour development, to map murine genes associated with susceptibility to lung carcinogenesis. An F2 population of urethan-treated A/J x C3H/He mice was scored with 83 genetic markers. A chromosome 6 distal region, spanning 35 centiMorgans, contained a major lung tumour susceptibility locus. No other chromosomal region was significantly associated with lung tumour development. |
| Document Type: Article |
| Language: English |
Addresses:
1. IST NAZL TUMORI, DIV EXPTL ONCOL A, I-20133 MILAN, ITALY
2. UNIV MILAN, DEPT GENET & MICROBIOL, I-20122 MILAN, ITALY |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: KL010 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |