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| ENDOTHELIUM-DERIVED RELAXING FACTOR, NITRIC-OXIDE - EFFECTS ON AND PRODUCTION BY MESANGIAL CELLS AND THE GLOMERULUS |
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| Author(s): RAIJ L, SHULTZ PJ |
| Source: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 3 Issue: 8 Pages: 1435-1441 Published: FEB 1993 |
| Times Cited: 69 References: 56 |
| Abstract: The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in cGMP, inhibit mesangial cell contraction, and inhibit growth factor-induced proliferation of mesangial cells in culture. Furthermore, incubation with endotoxin or cytokines stimulates mesangial cells to produce EDRF/NO, via an inducible NO synthase enzyme. Therefore, it is likely that NO could play a role in the inflammatory response within the glomerulus. Finally, recent studies providing evidence that EDRF/NO is functional within the glomerulus in vivo, especially during endotoxemia and inflammation are also reviewed. |
| Document Type: Editorial Material |
| Language: English |
Addresses:
1. VET ADM MED CTR, RENAL SECT 111J, 1 VET DR, MINNEAPOLIS, MN 55417 USA
2. UNIV MINNESOTA, MINNEAPOLIS, MN 55455 USA |
| Publisher: WILLIAMS & WILKINS, 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 |
| Subject Category: Urology & Nephrology |
| IDS Number: KN148 |
| ISSN: 1046-6673 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |