| | |  | | | | Record from Web of Science® | | | | | | |
| SUBSTANCE-ABUSE VULNERABILITY AND D2 RECEPTOR GENES |
|
|
| Author(s): UHL G, BLUM K, NOBLE E, SMITH S |
| Source: TRENDS IN NEUROSCIENCES Volume: 16 Issue: 3 Pages: 83-88 Published: MAR 1993 |
| Times Cited: 101 References: 36 |
| Abstract: Dopamine systems are key to the actions of several substances. Interindividual differences In genes encoding proteins involved In dopaminergic neurotransmission could plausibly explain some of the genetic bases for inter-individual differences in vulnerability to substance abuse. The restriction fragment length polymorphism (RFLP) markers TaqI A1 and B1 at the dopamine D2 receptor (DRD2) gene locus in Caucasians are associated with substance abuse behaviors, In most, but not all, studies of alcoholics and polysubstance abusers, these TaqI A1 and B1 gene markers are present more often in substance abusers than in control individuals. No study has identified substance abusers or controls by sampling randomly from the general population; allelic association findings could thus conceivably be confounded by RFLP differences based on ethnicity or other factors. However, meta-analyses of the data from controlled studies available to date are consistent with the proposal that DRD2 gene variants contribute to inter-individual differences in vulnerability to alcoholism and polysubstance abuse. |
| Document Type: Article |
| Language: English |
| Reprint Address: UHL, G (reprint author), NIDA, ADDICT RES CTR, MOLEC NEUROBIOL LAB, BOX 5180, BALTIMORE, MD 21224 USA |
Addresses:
1. NIDA, ADDICT RES CTR, ETIOL LAB, BALTIMORE, MD 21224 USA
2. UNIV TEXAS, HLTH SCI CTR, DEPT PHARMACOL, SAN ANTONIO, TX 78284 USA
3. UNIV WISCONSIN, DEPT PSYCHOL, MADISON, WI 53706 USA
4. JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21205 USA
5. JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROSCI, BALTIMORE, MD 21205 USA
6. UNIV CALIF LOS ANGELES, SCH MED, ALCOHOL RES CTR, LOS ANGELES, CA 90024 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Neurosciences |
| IDS Number: KN179 |
| ISSN: 0166-2236 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |