| PROGNOSTIC-SIGNIFICANCE OF HORMONE RECEPTORS IN ENDOMETRIAL CANCER |
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| Author(s): CREASMAN WT |
| Source: CANCER Volume: 71 Issue: 4 Pages: 1467-1467 Supplement: Suppl. S Published: FEB 15 1993 |
| Times Cited: 86 References: 8 |
| Abstract: Background. Endometrial carcinoma is the most common female pelvic genital malignancy. Many studies suggest that approximately 75% of all endometrial cancers are clinical Stage I. More than 50% of cancer deaths are in patients with clinical Stage I disease. As a result, prognostic factors have been evaluated in an attempt to identify those patients with presumed early stage disease who will be at high risk for recurrence. Recently, hormone receptor status (estrogen [ER], progesterone [PR]) in endometrial cancer has been suggested to be a prognostic factor. Methods. Two hundred seventeen patients with Stage I and II endometrial cancers were evaluated for cytoplasmic steroid-receptor status. These results were compared with other prognostic factors in both univariant and multivariant analysis.
Results. When ER and PR and combined ER/PR status were analyzed separately, patients with receptor-positive lesions had significantly better disease-free survival than those with receptor-negative lesions. The receptor status was also a significant independent prognostic factor when evaluated by stepwise proportional hazards regression analysis.
Conclusions. Hormone receptor status in endometrial cancer appears to be an important prognostic factor.
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| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: CREASMAN, WT (reprint author), MED UNIV S CAROLINA, DEPT OBSTET & GYNECOL, 171 ASHLEY AVE, CHARLESTON, SC 29425 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: KN467 |
| ISSN: 0008-543X |