| | |  | | | | Record from Web of Science® | | | | | | |
| STEM-CELL ORIGINS OF LEUKEMIA AND CURABILITY |
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| Author(s): GREAVES MF |
| Source: BRITISH JOURNAL OF CANCER Volume: 67 Issue: 3 Pages: 413-423 Published: MAR 1993 |
| Times Cited: 67 References: 140 |
| Abstract: It is suggested that most childhood acute lymphoblastic leukaemias an some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemo-sensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells. |
| Document Type: Review |
| Language: English |
| Reprint Address: GREAVES, MF (reprint author), INST CANC RES, CHESTER BEATTY LABS, CTR LEUKAEMIA RES FUND, 237 FULHAM RD, LONDON SW3 6JB, ENGLAND |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Oncology |
| IDS Number: KP200 |
| ISSN: 0007-0920 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |