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| A DNA APTAMER WHICH BINDS TO AND INHIBITS THROMBIN EXHIBITS A NEW STRUCTURAL MOTIF FOR DNA |
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| Author(s): WANG KY, MCCURDY S, SHEA RG, SWAMINATHAN S, BOLTON PH |
| Source: BIOCHEMISTRY Volume: 32 Issue: 8 Pages: 1899-1904 Published: MAR 2 1993 |
| Times Cited: 211 References: 27 |
| Abstract: The investigation of the three-dimensional structure of the DNA aptamer d(G1G2T3T4G5G6T7G8T9G10G11T12T13G14G15) which binds to and inhibits thrombin has been carried out by NMR methods. This DNA exhibits a number of long-range NOEs between residues which are not adjacent in sequence, which allowed the determination of the novel tertiary structure adopted. This DNA adopts a highly compact, highly symmetrical structure which consists of two tetrads of guanosine base pairs and three loops. The residues of the tetrads alternate anti-syn-anti-syn. This novel structural motif for DNA may also be relevant to the structure of telomere DNA. |
| Document Type: Note |
| Language: English |
Addresses:
1. GILEAD SCI, 346 LAKESIDE DR, FOSTER CITY, CA 94404 USA
2. WESLEYAN UNIV, DEPT CHEM, MIDDLETOWN, CT 06459 USA |
| Publisher: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: KP582 |
| ISSN: 0006-2960 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |