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| A POTENTIAL ROLE FOR SUPERANTIGENS IN THE PATHOGENESIS OF PSORIASIS |
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| Author(s): LEUNG DYM, WALSH P, GIORNO R, NORRIS DA |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 100 Issue: 3 Pages: 225-228 Published: MAR 1993 |
| Times Cited: 114 References: 24 |
| Abstract: Psoriasis is a complex inflammatory skin disease in which local vascular changes, T-cell activation, abnormal keratinocyte proliferation and differentiation, and neutrophil activation all contribute to the ongoing disease process. Because of recent interest in T-cell activation as a trigger for psoriatic lesions, we hypothesized that psoriasis may be triggered by superantigens, e.g., toxins of microbial origin that stimulate T cells expressing particular T-cell receptor (TCR) beta chain variable (Vbeta) gene segments. Lesional skin biopsies and peripheral blood from two patients with acute exacerbations of their psoriasis that appeared to be triggered by infection were analyzed for TCR Vbeta gene expression using monoclonal antibodies directed against Vbeta 5.1, 5.2, 6.7, 8.1, and 12. Skin biopsies from both patients demonstrated a different pattern of Vbeta expansion that corresponded to the Vbeta pattern expected to be induced by the type of superantigen expressed during the infection. In contrast, using immunofluorescence and flow cytometry, peripheral blood T cells from these patients did not demonstrate any expansion of the 5 Vbeta subsets studied. These observations support the hypothesis that local activation of cutaneous T cells in psoriasis may be caused by a superantigen and provides a new direction for investigating the pathogenesis of this complex and fascinating skin disorder. |
| Document Type: Article |
| Language: English |
| Reprint Address: LEUNG, DYM (reprint author), NATL JEWISH CTR IMMUNOL & RESP MED, DEPT PEDIAT, 1400 JACKSON ST, DENVER, CO 80206 USA |
Addresses:
1. UNIV COLORADO, HLTH SCI CTR, DEPT PEDIAT, DENVER, CO 80262 USA
2. UNIV COLORADO, HLTH SCI CTR, DEPT DERMATOL, DENVER, CO 80262 USA
3. UNIV COLORADO, HLTH SCI CTR, DEPT IMMUNOL, DENVER, CO 80262 USA |
| Publisher: BLACKWELL SCIENCE INC, 238 MAIN ST, CAMBRIDGE, MA 02142 |
| Subject Category: Dermatology |
| IDS Number: KR121 |
| ISSN: 0022-202X |
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