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| CYCLOSPORINE-A PROLONGS HUMAN HAIR-GROWTH INVITRO |
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| Author(s): TAYLOR M, ASHCROFT ATT, MESSENGER AG |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 100 Issue: 3 Pages: 237-239 Published: MAR 1993 |
| Times Cited: 35 References: 16 |
| Abstract: We studied the effect of cyclosporin A on human hair growth using a recently described model in which isolated hair follicles are grown in vitro. Cyclosporin A had no effect on the rate of hair growth, but at 10(-7) M, a dose within the therapeutic blood range, it maintained hair growth for longer than control to give a 42% greater mean follicle elongation after 15 d (p < 0.05). Eighteen of 42 cyclosporin-treated follicles (43%) were still growing after 15 d compared with one of 42 control follicles (2%). These results suggest that the hypertrichotic action of cyclosporin A may be due to prolongation of the anagen phase of the hair-growth cycle. |
| Document Type: Article |
| Language: English |
| Reprint Address: TAYLOR, M (reprint author), UNIV SHEFFIELD, ROYAL HALLAMSHIRE HOSP, DEPT DERMATOL, FLOOR 0, GLOSSOP RD, SHEFFIELD S10 2JF, S YORKSHIRE ENGLAND |
| Publisher: BLACKWELL SCIENCE INC, 238 MAIN ST, CAMBRIDGE, MA 02142 |
| Subject Category: Dermatology |
| IDS Number: KR121 |
| ISSN: 0022-202X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |