| | |  | | | | Record from Web of Science® | | | | | | |
| GENISTEIN ARRESTS CELL-CYCLE PROGRESSION AT G(2)-M |
|
|
| Author(s): MATSUKAWA Y, MARUI N, SAKAI T, SATOMI Y, YOSHIDA M, MATSUMOTO K, NISHINO H, AOIKE A |
| Source: CANCER RESEARCH Volume: 53 Issue: 6 Pages: 1328-1331 Published: MAR 15 1993 |
| Times Cited: 243 References: 34 |
| Abstract: Genistein, an isoflavone, is a specific inhibitor of tyrosine kinase and topoisomerase II. However, its effect on cell growth is unknown. Therefore, we examined the effects of genistein on cell growth and cell cycle progression and compared its effects with other flavonoids. Genistein inhibited in a dose-dependent manner the growth of HGC-27 cells derived from human gastric cancer. Flow-cytometric analysis showed that genistein almost completely arrested the cell cycle progression at G2-M. This effect was reversible when genistein was removed from the culture medium. In contrast, other flavonoids such as flavone, luteolin, and the structurally similar daidzein arrested the cell cycle at G1. Consistent with the flow-cytometric analysis, microscopic observation showed that genistein did not increase the mitotic index, which supposes that genistein may arrest the cell cycle at G2 or early M. These results suggest that the G2-M arrest by genistein is a unique effect among flavonoids. |
| Document Type: Article |
| Language: English |
| Reprint Address: MATSUKAWA, Y (reprint author), KYOTO PREFECTURAL UNIV MED, DEPT PREVENT MED, KAMIKYO KU, KYOTO 602, JAPAN |
Addresses:
1. KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN
2. HYOGO INST ORIENTAL MED, AMAGASAKI, HYOGO 660 JAPAN |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: KR297 |
| ISSN: 0008-5472 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |