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| IMMUNE-RESPONSE IN MICE THAT LACK THE INTERFERON-GAMMA RECEPTOR |
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| Author(s): HUANG S, HENDRIKS W, ALTHAGE A, HEMMI S, BLUETHMANN H, KAMIJO R, VILCEK J, ZINKERNAGEL RM, AGUET M |
| Source: SCIENCE Volume: 259 Issue: 5102 Pages: 1742-1745 Published: MAR 19 1993 |
| Times Cited: 1,086 References: 34 |
| Abstract: Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance; they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ZURICH, INST MOLEC BIOL 1, CH-8093 ZURICH, SWITZERLAND
2. F HOFFMANN LA ROCHE & CO LTD, DEPT PHARMACEUT RES NEW TECHNOL, CH-4002 BASEL, SWITZERLAND
3. UNIV ZURICH, INST EXPTL IMMUNOL, CH-8057 ZURICH, SWITZERLAND
4. NYU MED CTR, DEPT MICROBIOL, NEW YORK, NY 10016 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: KT810 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |